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Structural imaging

LAC lab, CBC lab, ASC lab

全/大組織結構影像可以用來分析例如全鼠腦的神經、細胞影像並取得定量化的結果。透過全組織透明化及高速染色技術,我們可以快速的取得從鼠腦到人體組織檢體的完整影像。而利用定位顯微鏡(Localization microscopy)或是組織膨脹 (Tissue expansion),則可以輕易的突破光學解析度,拿到數十奈米解析度的影像資料。

Whole organ clearing and labeling preserve whole brain neuronal structures which allows us to understand the brain in a whole brain manner.

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in collaboration with Nebulum technologies 

https://nebulumtech.com/

This mouse brain was cleared with water base protocol.

Protocol credit: Xuejiao Tian, Academia Sinica

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LLM-CT (Lightsheet localization microscopy for clarified tissue) is the first localization microscopy that can be used to image the entire fly brain with 50 nm resolution

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LLExM is a methods that combines 4x sample expansion technologies and lattice light sheet microscopy to capture optical image in 60 nm. 

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LLExM-Max is a methods that combines 10x sample expansion technologies and lattice light sheet microscopy to capture optical image in 20 nm. 

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